About
Reactome is an open, peer-reviewed pathway database. As a graph it is 2,978,202 nodes and 11,537,843 edges of reactions, proteins and pathways, connected densely enough that one question crosses many relationship types.
Evaluation
Variable-depth traversals from one to twenty hops, returning every distinct endpoint reached. Run cold on an Intel Core Ultra 7 265, 20 cores and 64G RAM, with no caching, no indexing and no tuning.
Result
TuringDB returns at every depth, from 4.73 ms at one hop to 5,876.51 ms at twenty. The others stop between eight and ten hops on out-of-memory or timeout. Across the 36 completed comparisons the geometric mean speedup is 38x.